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Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability
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Single-Atom Catalysts for Biotherapy Applications: A Systematic Review.

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Single-atom catalysts (SACs) show great promise for biotherapy, including anticancer and anti-infection treatments. These advanced materials offer superior therapeutic effects with good biocompatibility, warranting further research.

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Area of Science:

  • Nanotechnology
  • Catalysis
  • Biomedical Science

Background:

  • Single-atom catalysts (SACs) feature atomically dispersed metal active sites on supports.
  • SACs mimic natural enzymes with high catalytic activity, stability, and selectivity.
  • Their unique structure presents potential for therapeutic applications.

Purpose of the Study:

  • To systematically review and synthesize evidence on the biotherapy applications of SACs.
  • To evaluate the therapeutic efficacy and biocompatibility of various SACs.
  • To identify the potential of SACs in treating diverse diseases.

Main Methods:

  • A systematic literature search was conducted across PubMed/MEDLINE, ISI Web of Science, and ScienceDirect.
  • Studies investigating the therapeutic efficacy of SACs were identified and included.
  • A qualitative synthesis of key findings from 12 selected studies was performed.

Main Results:

  • Various SACs demonstrated efficacy in anticancer, anti-infection, anti-inflammatory, brain trauma, and oxidative stress applications.
  • All reviewed SACs exhibited superior therapeutic effects compared to controls.
  • Eleven studies reported satisfactory biocompatibility, with one study noting minimal cytotoxicity.

Conclusions:

  • Single-atom catalysts show considerable promise as a new class of therapeutic agents.
  • SACs offer significant potential for diverse biotherapy applications.
  • Further research is necessary to fully understand SACs' therapeutic effects and optimize their clinical use.