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The role of plasma cells in scleroma. Electron-microscopic study
Abstract:
Three cases of rhinoscleroma in the granulomatous stage were examined under the electrom microscope. The rough endoplasmic reticulum of plasma cells in scleroma displayed cisternal dilatations forming Russell bodies and cytoplasmic vacuolations containing viable and degenerated bacilli forming Mikulicz cells. Thus, they play a double role, producing antibodies and providing protection for the intracellular bacilli. New ultrastructural findings of Klebsiella rhinoscleromatic bacilli were described.
Insights
Rhinoscleroma plasma cells have a dual role in granulomatous inflammation, producing antibodies and harboring Klebsiella rhinoscleromatic bacilli within Mikulicz cells. This study reveals new ultrastructural details of these bacilli and their interaction with host cells.
Area of Science:
- Microbiology
- Pathology
- Cell Biology
Background:
- Rhinoscleroma is a chronic granulomatous disease affecting the upper respiratory tract.
- The role of plasma cells and Klebsiella rhinoscleromatic in disease pathogenesis is not fully understood.
- Previous studies have lacked detailed ultrastructural analysis of the granulomatous stage.
Purpose of the Study:
- To investigate the ultrastructural morphology of plasma cells and Klebsiella rhinoscleromatic bacilli in rhinoscleroma.
- To elucidate the role of plasma cells in housing and protecting intracellular bacteria.
- To describe novel ultrastructural findings of Klebsiella rhinoscleromatic.
Main Methods:
- Electron microscopy was used to examine three cases of rhinoscleroma in the granulomatous stage.
- Ultrastructural analysis focused on plasma cells and associated bacilli.
- Morphological features of endoplasmic reticulum, Russell bodies, and Mikulicz cells were documented.
Main Results:
- Plasma cells exhibited dilated rough endoplasmic reticulum forming Russell bodies.
- Cytoplasmic vacuoles within plasma cells contained viable and degenerated Klebsiella rhinoscleromatic bacilli, forming Mikulicz cells.
- New ultrastructural details of Klebsiella rhinoscleromatic bacilli were observed.
Conclusions:
- Plasma cells in rhinoscleroma play a dual role: antibody production and intracellular bacterial protection.
- Mikulicz cells represent a mechanism for housing Klebsiella rhinoscleromatic within host cells.
- The findings provide new insights into the cellular mechanisms of rhinoscleroma pathogenesis.