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Partnerships in Research to Implement and Disseminate Sustainable and Scalable Evidence-Based Practices (PRIDE) in
Milton L Wainberg1, Kathryn L Lovero1, Cristiane S Duarte1
1Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York City (Wainberg, Lovero, Duarte, Fiks Salem, Milena Mello, Mootz, Weissman, Cournos, Alves-Bradford, Wall); Research Unit, Foundation for Professional Development, Pretoria, South Africa (Bezuidenhout, Ngwepe, Medina-Marino); Hospital Psiquiatrico Nampula, Nampula, Mozambique (Feliciano, Suleman); Mental Health Department, Ministry of Health, Maputo, Mozambique (Fortunato dos Santos, Fumo, Mocumbi, Gouveia); National Institute of Mental Health (NIMH), Bethesda, Maryland (Marques); Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique (Mabunda, Mocumbi); Department of Psychobiology and Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, Brazil (Marcelo Mello, Mari); Department of Psychiatry and Center for Mental Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia (Cidav, Oquendo).
Background:
Mental health conditions impose a major burden worldwide, especially in low- and middle-income countries (LMICs), where health specialists are scarce. A challenge to closing LMICs' mental health treatment gap is determining the most cost-effective task-shifting pathway for delivering mental health services using evidence-based interventions (EBIs). This article discusses the protocol for the first study implementing comprehensive mental health services in LMICs.
Methods:
In partnership with the Mozambican Ministry of Health, this cluster-randomized, hybrid implementation effectiveness type-2 trial will evaluate implementation, patient, and service outcomes of three task-shifting delivery pathways in 20 Mozambican districts (population 4.7 million). In pathway 1 (usual care), community health workers (CHWs) and primary care providers (PCPs) refer patients to district-level mental health clinics. In pathway 2 (screen, refer, and treat), CHWs screen and refer patients to PCPs for behavioral and pharmacological EBIs in community clinics. In pathway 3 (community mental health stepped care), CHWs screen patients and deliver behavioral EBIs in the community and refer medication management cases to PCPs in clinics. Mixed-methods process evaluation will be used to examine factors affecting pathway implementation, adoption, and sustainability. Clinical activities will occur without research team support. Ministry of Health personnel will coordinate training and supervision.
Results:
The most cost-effective pathway will be scaled up in all districts for 12 months.
Next Steps:
This novel study integrating comprehensive mental health services into primary care will inform a toolkit to help the Mozambican Ministry of Health scale up the most cost-effective pathway for mental health services and can be a template for other LMICs.
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