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Two new 2-phenylethylchromones from artificial agarwood by holing method
Pan Xiang1, Yan-Bo Zeng1, Hao Wang1
1Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Journal of Asian Natural Products Research
|December 18, 2020
Summary
Two novel 2-(2-phenylethyl)chromone derivatives were identified in artificial agarwood from Aquilaria sinensis. These compounds exhibited weak inhibitory activity against acetylcholinesterase.
Area of Science:
- Natural Product Chemistry
- Pharmacognosy
- Medicinal Chemistry
Background:
- Agarwood, produced by Aquilaria species, is a valuable resinous material used in traditional medicine and perfumery.
- The holing method is employed to induce agarwood formation in Aquilaria trees.
- Aquilaria sinensis is a key species in agarwood production.
Purpose of the Study:
- To isolate and characterize new chemical compounds from artificial agarwood of Aquilaria sinensis.
- To investigate the potential bioactivity of the isolated compounds, specifically their effect on acetylcholinesterase.
Main Methods:
- Extraction of artificial agarwood using ethyl acetate.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation through comprehensive spectroscopic analyses (UV, IR, NMR, HRESIMS).
- In vitro bioassay for acetylcholinesterase inhibitory activity.
Main Results:
- Two new 2-(2-phenylethyl)chromone derivatives, designated compounds 1 and 2, were successfully isolated.
- The structures of compounds 1 and 2 were confirmed by detailed spectroscopic data.
- Compounds 1 and 2 demonstrated weak inhibitory activity against acetylcholinesterase at a concentration of 50.0 μg/ml.
Conclusions:
- The study reports the first isolation of 2-(2-phenylethyl)chromone derivatives from the Aquilaria genus.
- The identified compounds represent novel chemical entities with potential, albeit weak, neuropharmacological activity.
- Further research may explore structural modifications to enhance the acetylcholinesterase inhibitory properties.
