Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

461
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
461
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

598
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
598
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

386
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
386
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

524
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
524
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

1.0K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.0K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

679
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
679

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Platelet-derived vesicles restore fertility in endometrial injury by modulating the endometrial immune niche in mice.

Science advances·2026
Same author

A Dual-Channel Self-Calibrated Fluorescent Probe for the Correlation of Nitroreductase Activity and DNA Damage.

Analytical chemistry·2026
Same author

Sam68 Exacerbates Pathologic Cardiac Hypertrophy by Suppressing Cardiomyocyte Glucose Oxidation.

Circulation·2026
Same author

Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis.

Nature communications·2026
Same author

Copper-Mediated Bis(trifluoromethyl)carbinolation of Arylboronic Acids Enabled by Iodobis(trifluoromethyl)carbinol Ester.

Organic letters·2026
Same author

Early trajectories of antibiotic exposure and colonization pressure and risk of ICU-acquired carbapenem-resistant Gram-negative bacteria: A prospective cohort study.

Annals of intensive care·2026
Same journal

Clinical management and genetic variation analysis of patients with 17β-hydroxysteroid dehydrogenase deficiency.

The Journal of international medical research·2026
Same journal

Totally implantable venous access port implantation in a breast cancer patient with situs inversus totalis: A case report.

The Journal of international medical research·2026
Same journal

An adaptive attention U-network for recognizing ultrasound images.

The Journal of international medical research·2026
Same journal

Examining the state of telehealth for mental health and substance use care after the coronavirus disease 2019 pandemic: An integrative review.

The Journal of international medical research·2026
Same journal

Effects of adrenal ablation on blood pressure and target organ damage in deoxycorticosterone acetate-salt hypertensive rats.

The Journal of international medical research·2026
Same journal

Regional citrate versus systemic heparin anticoagulation in continuous renal replacement therapy for sepsis-associated acute kidney injury: A retrospective cohort study of short-term outcomes.

The Journal of international medical research·2026
See all related articles

Related Experiment Video

Updated: Nov 25, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.7K

Pregabalin does not decrease acute pain or postoperative nausea and vomiting after hysterectomy: a meta-analysis.

Jie Ni1, Juan Jiang1, Shiqin Mao1

  • 1Department of Gynecology, Jingjiang People's Hospital, Taizhou, Jiangsu Province, China.

The Journal of International Medical Research
|December 18, 2020
PubMed
Summary
This summary is machine-generated.

Pregabalin offers limited pain relief after hysterectomy, showing no significant difference from placebo for pain intensity. However, it effectively reduces postoperative nausea and vomiting, warranting further research.

Keywords:
Pregabalinacute painhysterectomymeta-analysismorphine consumptionpostoperative pain

More Related Videos

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

48.9K
Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery
05:39

Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery

Published on: June 23, 2023

1.8K

Related Experiment Videos

Last Updated: Nov 25, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.7K
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

48.9K
Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery
05:39

Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery

Published on: June 23, 2023

1.8K

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Gynecologic Surgery

Background:

  • Hysterectomy frequently causes severe postoperative pain.
  • The effectiveness of pregabalin for managing post-hysterectomy pain requires clarification.

Purpose of the Study:

  • To evaluate the efficacy of pregabalin versus placebo in reducing pain after hysterectomy.
  • To assess pregabalin's impact on pain intensity and morphine consumption.

Main Methods:

  • A systematic literature search was conducted across PubMed, Cochrane Library, and Web of Science.
  • Included studies compared pregabalin with placebo for pain management in hysterectomy patients.

Main Results:

  • Pregabalin demonstrated limited pain relief at 2, 6, 24, and 48 hours post-surgery compared to placebo.
  • A significant reduction in postoperative nausea and vomiting was observed with pregabalin.
  • No significant differences in sedation or visual disturbances were found between groups.

Conclusions:

  • Pregabalin is not clinically superior to placebo for reducing pain intensity or morphine use after hysterectomy.
  • Limitations necessitate high-quality randomized controlled trials to confirm these findings.