Related Experiment Video
Updated: Nov 25, 2025
07:58
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
Published on: July 17, 2016
9.1K
Community-Acquired AKI in Asia: An Update
1Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Seminars in Nephrology
|December 18, 2020
Summary
Community-acquired acute kidney injury (CA-AKI) in Asia is influenced by socioeconomic factors and environmental exposures. Infections like dengue and scrub typhus are rising, impacting kidney health and potentially leading to chronic kidney disease.
Area of Science:
- Nephrology
- Infectious Diseases
- Public Health
Background:
- Community-acquired acute kidney injury (CA-AKI) is prevalent in Asian developing countries, shaped by socioeconomic and environmental factors.
- Diverse causes include infections, toxins, envenomations, and obstetric complications, affecting young, outdoor workers.
- Evolving disease understanding reveals changing patterns and new associations over two decades.
Purpose of the Study:
- To review the epidemiology, causes, and evolving landscape of CA-AKI in Asian developing countries.
- To highlight emerging infectious causes and long-term consequences of CA-AKI.
- To identify areas for improved research and clinical outcomes.
Main Methods:
- Literature review and synthesis of epidemiological data on CA-AKI in Asia.
- Analysis of trends in infectious etiologies and associated risk factors.
- Examination of novel findings regarding AKI, chronic kidney disease, and complement pathways.
Main Results:
- Infections like dengue and scrub typhus are increasing, while malaria incidence declines.
- New associations found between AKI and Plasmodium species, scrub typhus, leptospirosis, and potential progression to chronic kidney disease.
- Decreases in CA-AKI from diarrheal illness and obstetric causes are noted; snake envenomation remains a concern.
Conclusions:
- CA-AKI in Asia presents unique challenges due to socioeconomic and environmental factors.
- Increased incidence of certain infections and their link to long-term kidney damage necessitate targeted interventions.
- Collaborative efforts are crucial for advancing research and improving CA-AKI patient outcomes.
Related Concept Videos
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
148
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
148
01:22Acute Kidney Injury I: Introduction
300
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
300
01:20Acute Kidney Injury V: Interprofessional Care
138
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
138
01:29Acute Kidney Injury II: Pathophysiology
568
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
568
01:29Acute Kidney Injury III: Clinical Manifestations
469
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
469
01:22Acute Kidney Injury VI: Nursing Management
203
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
203