ERS statement on chronic thromboembolic pulmonary hypertension

Area of Science:

• Cardiology
• Pulmonary Medicine
• Vascular Surgery

Background:

• Chronic thromboembolic pulmonary hypertension (CTEPH) arises from unresolved pulmonary embolism, leading to pulmonary vascular resistance and right heart failure.
• The transformation of blood clots into fibrotic material in pulmonary arteries remains poorly understood.
• Diagnosis involves ventilation/perfusion scans, right heart catheterization, and vascular imaging.

Purpose of the Study:

• To provide a comprehensive review of the current literature and clinical practices for CTEPH diagnosis and management.
• To consolidate knowledge on CTEPH epidemiology, pathophysiology, and treatment options.
• To highlight emerging research and collaborative efforts in the field.

Main Methods:

• Literature review and synthesis of current practices.
• Analysis of diagnostic criteria and imaging modalities.
• Evaluation of therapeutic interventions including surgery, angioplasty, and medical treatments.

Main Results:

• CTEPH diagnosis relies on specific imaging and hemodynamic assessments.
• Treatment strategies are tailored to lesion characteristics and include surgery, angioplasty, and pharmacotherapy.
• Lifelong anticoagulation is a standard component of CTEPH management.

Conclusions:

• This statement summarizes current understanding of CTEPH, covering its definition, diagnosis, pathophysiology, and treatment.
• It emphasizes the multidisciplinary approach required for effective CTEPH management.
• While not providing formal recommendations, it serves as a valuable resource for clinicians and researchers.