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Updated: Aug 9, 2026
09:37
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
Strategies to control cancer through genetics
1Institute of Medical Genetics, University of Oslo, Norway.
Princess Takamatsu Symposia
|January 1, 1987
Summary
Identifying genetic predisposition to cancer is crucial. Recognizing specific cancer patterns and family history can indicate increased cancer risk, guiding genetic evaluation and preventative strategies.
Area of Science:
- Oncology
- Human Genetics
- Preventative Medicine
Background:
- Genetic factors play a role in a subset of common cancers.
- Identifying individuals with increased cancer susceptibility is essential for early intervention.
- Cancer occurrence patterns can signal underlying genetic predispositions.
Purpose of the Study:
- To outline criteria for identifying individuals who may have an increased susceptibility to cancer due to genetic factors.
- To describe strategies for controlling cancer by leveraging genetic knowledge.
- To emphasize the importance of genetic evaluation in cancer prevention.
Main Methods:
- Review of clinical indicators of potential genetic predisposition to cancer (e.g., multifocal tumors, atypical age/site, family history).
- Identification of high-risk individuals, including first-degree relatives and those with specific cancer patterns.
- Outline of a cancer control strategy incorporating genetic counseling, prenatal diagnosis, surveillance, prophylactic measures, and environmental factor management.
Main Results:
- Specific cancer occurrences (e.g., bilateral in paired organs, multiple primary malignancies, early onset) suggest increased malignancy risk.
- Family history, including multiple affected first-degree relatives, is a key indicator of genetic risk.
- A comprehensive strategy involving genetic counseling, surveillance, and lifestyle modifications can aid cancer control.
Conclusions:
- Genetic evaluation is important for individuals exhibiting certain cancer patterns or with a relevant family history.
- Proactive genetic assessment and tailored interventions can significantly impact cancer prevention and management.
- Advancements in human ecogenetics and molecular genetics will enhance the application of genetic knowledge in cancer control.
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