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Updated: Nov 25, 2025
12:40
Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
Published on: April 6, 2015
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Basophils and Eosinophils in Nematode Infections
Kazushige Obata-Ninomiya1, Phillip P Domeier1, Steven F Ziegler1,2
1Immunology Program, Benaroya Research Institute, Seattle, WA, United States.
Frontiers in Immunology
|December 18, 2020
Summary
Helminths are common pathogens. Type 2 epithelial cytokines induce immune responses, with basophils and eosinophils playing key roles in combating nematode infections and offering therapeutic potential.
Area of Science:
- Immunology
- Parasitology
Background:
- Helminths are globally prevalent pathogens infecting various epithelial surfaces.
- Epithelial cells release Type 2 epithelial cytokines (TSLP, IL-33, IL-25) initiating innate and acquired type 2 immune responses.
Purpose of the Study:
- To investigate the roles of basophils and eosinophils in type 2 immunity against helminth infections.
- To explore the non-redundant functions of these granulocytes in distinct nematode responses.
Main Methods:
- Analysis of immune cell frequency during type 2 immunity.
- Evaluation of effector functions and response modulation by basophils and eosinophils.
Main Results:
- Basophils and eosinophils, though rare normally, increase in type 2 immunity, including helminth infections.
- These cells exhibit effector functions and actively shape the immune response to helminths.
- Basophils and eosinophils demonstrate non-redundant roles in combating different nematode species.
Conclusions:
- Basophils and eosinophils are crucial players in type 2 immunity against helminths.
- Their distinct roles offer potential targets for developing novel vaccines and therapeutics for nematode infections.
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