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Updated: Nov 25, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and Biological Evaluations of Electrophilic Steroids Inspired by the Taccalonolides
Nicholas A Clanton1, Shayne D Hastings2, Griffin B Foultz1
1Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Abstract:
Natural products have served as inspirational scaffolds for the design and synthesis of novel antineoplastic agents. Here we present our preliminary efforts on the synthesis and biological evaluation of a new class of electrophilic steroids inspired by the naturally occurring taccalonolides. We demonstrate that these simplified analogs exhibit highly persistent antiproliferative properties similar to the taccalonolides and retain activity against resistant cancer cell lines that warrants further preclinical development.
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