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Updated: Nov 25, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
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Voltage-dependent anion channels mediated apoptosis in refractory epilepsy

Yan Zhao1, Wen-Jing Jiang1, Lin Ma1

  • 1Department of Geriatric Medicine, Shandong Key Laboratory of Cardiovascular Proteomics, Qilu Hospital of Shandong University, Jinan, 250012, Shandong Province, China.

Open Medicine (Warsaw, Poland)
|December 18, 2020
PubMed
Summary

Voltage-dependent anion channel 1 (VDAC1) significantly contributes to neuron apoptosis in refractory epilepsy by promoting the release of cytochrome C. Targeting VDAC1 may offer a new therapeutic strategy for epilepsy treatment.

Keywords:
VDACapoptosisrefractory epilepsy

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