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Published on: August 28, 2018
Serum calcium levels correlates with coronary artery disease outcomes
Mian Wang1,2, Shaodi Yan3, Yong Peng3
1Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, Shenzhen, 518057, China.
Insights
Higher serum calcium levels are linked to better outcomes in coronary artery disease (CAD) patients. This finding suggests serum calcium can predict mortality risk in individuals with CAD.
Area of Science:
- Cardiology
- Clinical Biochemistry
Background:
- Prognostic value of serum calcium in coronary artery disease (CAD) is not well established.
- Investigating the association between baseline serum calcium and patient outcomes is crucial.
Purpose of the Study:
- To assess the relationship between baseline serum calcium levels and short-term and long-term outcomes in patients with CAD.
- To determine if serum calcium can independently predict mortality in CAD patients.
Main Methods:
- Included 3,109 patients with confirmed coronary artery disease.
- Categorized patients into quartiles based on admission serum calcium levels.
- Utilized multivariable regression analysis to examine associations with mortality.
Main Results:
- Patients in higher serum calcium quartiles showed reduced all-cause, cardiovascular, and in-hospital mortality compared to the lowest quartile.
- Hazard ratios indicated significant inverse associations for mortality across upper quartiles.
- Consistent findings were observed in subgroup analyses including acute coronary syndrome (ACS) and stable CAD patients.
Conclusions:
- Serum calcium levels are inversely associated with coronary artery disease.
- Baseline serum calcium is an independent predictor of both in-hospital and long-term mortality in CAD patients.
Background:
Effect of serum calcium levels on prognosis of patients with coronary artery disease (CAD) is not well evaluated. We aimed to assess the associations of baseline serum calcium levels with both short-term and long-term outcomes in CAD patients.
Methods:
This study included 3,109 consecutive patients with angiographically confirmed CAD. Patients were categorized into quartiles according to admission serum calcium. Multivariable regression analysis was used to determine the association of serum calcium with mortality.
Results:
Compared to patients in the lowest quartile of serum calcium, patients in upper quartiles were presented with lower all-cause mortality (Hazard ratios [HRs] were -0.636 [95% CI: -0.424 to -0.954], -0.545 [95% CI: -0.351 to -0.846] and -0.641 [95% CI: -0.450 to -0.913] for three upper quartiles versus lowest quartile respectively), cardiovascular mortality (HRs 0.594 [0.368-0.961], 0.261 [0.124-0.551] and 0.407 [0.229-0.725]), and in-hospital mortality (Odd ratios [ORs] 0.391 [0.188-0.812], 0.231 [0.072-0.501] and 0.223 [0.093-0.534]). Consistent associations between serum calcium and long-term mortality were also obtained in subgroup analysis of ACS patients, stable CAD patients and discharged patients.
Conclusions:
Serum calcium is inversely associated with CAD and can independently predict both in-hospital and long-term mortality among CAD patients.
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