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Related Experiment Video

Updated: Nov 25, 2025

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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Integrase inhibitor-based antiretroviral treatments decrease oxidative stress caused by HIV infection.

Y Akkoyunlu1, A Kocyigit, G Okay

  • 1Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakif University, Istanbul, Turkey. yaseminakkoyunlu@gmail.com.

European Review for Medical and Pharmacological Sciences
|December 18, 2020
PubMed
Summary

Integrase inhibitor-based antiretroviral therapy significantly reduces oxidative stress in people living with HIV. This treatment shows promise for managing HIV-related oxidative stress and improving patient health.

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Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Oxidative stress is linked to chronic illnesses, including HIV infection.
  • Some antiretroviral therapies can exacerbate oxidative stress despite reducing viral load.

Purpose of the Study:

  • To investigate oxidative stress parameters and thiol-disulphide homeostasis in people living with HIV on integrase inhibitor-based antiretroviral therapy.

Main Methods:

  • Prospective enrollment of 30 treatment-naive HIV patients and 30 healthy controls.
  • Serum analysis for total antioxidant status (TAS), total oxidative status (TOS), malondialdehyde (MDA), and protein carbonyl (PC).
  • Flow cytometry for CD4+ T-cell counts; calculation of oxidative stress index (OSI) and disulfide levels (DIS).

Main Results:

  • Elevated TOS, OSI, MDA, and PC levels in treatment-naive HIV patients compared to those on ART.
  • Lower total and native thiol levels in both HIV-infected groups versus controls.
  • Positive correlation between TAS and CD4+ T-cell count in treatment-naive HIV patients.

Conclusions:

  • Integrase inhibitor-based ART effectively decreases HIV-associated oxidative stress.
  • This therapy represents a beneficial option for managing oxidative stress in individuals with HIV.