Color Tuning of Fluorogens for FAST Fluorogen-Activating Protein
Ivan N Myasnyanko1, Alexey S Gavrikov1, Snizhana O Zaitseva1
1Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997, Moscow, Russia.
Abstract:
Using benzylidene imidazolone core, we created a panel of color-shifted fluorogenic ligands for FAST protein without compromise to the binding efficiency and the utility for live-cell protein labeling. This study highlights the potential of benzylidene imidazolones derivatives for rapid expansion of a pallet of live-cell fluorogenic labeling tools.
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