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Techniques, perspectives, and challenges of bioactive peptide generation: A comprehensive systematic review
Meisam Barati1, Fardin Javanmardi2, Seyed Mohammad Hosein Mousavi Jazayeri3
1Student Research Committee, Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Comprehensive Reviews in Food Science and Food Safety
|December 18, 2020
Summary
Bioactive peptides (BPs) offer significant health benefits but current generation methods face limitations. New in-vivo and in-silico approaches are needed for effective BP identification and application.
Area of Science:
- Biochemistry
- Food Science
- Pharmacology
Background:
- Bioactive peptides (BPs) possess unique structures enabling significant biological effects.
- Their application is hindered by limitations in current generation and characterization methodologies.
Purpose of the Study:
- To systematically review and compile methods for generating bioactive peptides.
- To analyze current in vitro, in vivo, and in silico approaches for BP identification.
- To highlight the need for advanced methods in BP research.
Main Methods:
- Systematic literature review of publications up to April 2019.
- Screening of PubMed and Scopus databases for relevant studies.
- Analysis of enzymatic and microbial in vitro methods for BP characterization.
Main Results:
- In vitro methods (enzymatic, microbial) are common but insufficient for gastrointestinal tract stimulation.
- Existing methods present obstacles for effective bioactive peptide generation.
- A gap exists in robust in vivo and in silico approaches for BP identification.
Conclusions:
- Current in vitro methods for bioactive peptide generation require significant improvement.
- Development of novel in vivo and in silico strategies is crucial for advancing BP research.
- Future research should focus on overcoming limitations of existing methods for enhanced BP utilization.
