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Updated: Nov 25, 2025

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
Published on: December 15, 2023
Circadian effects on stroke outcome - Did we not wake up in time for neuroprotection?
Johannes Boltze1, Nadine Didwischus1, Martha Merrow2
1School of Life Sciences, University of Warwick, Coventry, UK.
Abstract:
The occurrence of stroke in humans peaks in the morning. A recent study revealed that time of day mitigates the therapeutic impact of neuroprotective paradigms. These findings might not only explain the previous failure of translation of neuroprotective therapies but inspire new paradigms in stroke chronopathophysiology research. Taking chronotype into account may complement the many factors that influence efficacy of experimental therapies in stroke.
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