The gut microbiome, endocannabinoids and metabolic disorders

Area of Science:

• Metabolic Science
• Microbiome Research
• Neuroendocrinology

Background:

• The gut microbiome and endocannabinoidome are critical regulators of energy metabolism.
• Both systems are implicated in the pathophysiology of obesity and metabolic disorders.
• Dysregulation of these systems can negatively impact peripheral organs and the brain.

Purpose of the Study:

• To explore the regulation and dysregulation of the gut microbiome and endocannabinoidome in energy metabolism.
• To emphasize the functional interactions between the gut microbiome and endocannabinoidome.
• To discuss potential therapeutic strategies targeting these systems for obesity and related conditions.

Main Methods:

• Review and synthesis of current literature on the gut microbiome and endocannabinoidome.
• Analysis of their roles in energy homeostasis and metabolic disease.
• Exploration of inter-system communication and potential therapeutic targets.

Main Results:

• The gut microbiome and endocannabinoidome possess extensive regulatory roles in energy balance.
• Obesity and poor dietary habits disrupt both systems, exacerbating metabolic dysfunction.
• Emerging evidence highlights significant functional crosstalk between the microbiome and endocannabinoidome.

Conclusions:

• The interplay between the gut microbiome and endocannabinoidome is crucial for metabolic health.
• Targeting these interconnected systems offers promising avenues for novel pharmacological and nutritional interventions against obesity.