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Emerging trends in chromatin remodeler plasticity in mesenchymal stromal cell function
Sayan Chakraborty1,2, Sayantani Sinha1,2, Amitava Sengupta1,2
1Stem Cell & Leukemia Laboratory, Cancer Biology & Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Summary
Epigenetic regulation influences mesenchymal stem/stromal cell (MSC) activity and tissue identity. Understanding MSC epigenomes is key for regenerative medicine and immune reprogramming.
Area of Science:
- Chromatin biology
- Stem cell biology
- Immunology
Background:
- Epigenetic regulation and chromatin remodeling are crucial for mesenchymal stem/stromal cell (MSC) activity, lineage commitment, and tissue identity.
- MSC homeostasis disruption impacts hematopoietic stem/progenitor cell function and immune regulation.
- MSCs contribute to immunosuppressive microenvironments, influencing antitumor immunity.
Purpose of the Study:
- To review the latest developments in chromatin biology concerning MSC function.
- To highlight the role of epigenetics in MSC lineage commitment and immunomodulation.
- To explore the therapeutic potential of understanding MSC epigenomes.
Main Methods:
- Review of recent literature on epigenetic regulation in MSCs.
- Analysis of chromatin remodeling complexes and transcription factor modulation.
- Discussion of signaling cues influencing MSC plasticity.
Main Results:
- Epigenetic mechanisms are central to gene regulation and tissue identity establishment in MSCs.
- Modulating transcription factors and chromatin architecture can regulate MSC activity and rejuvenation.
- MSCs play a significant role in immune regulation and shaping antitumor immunity.
Conclusions:
- Understanding the mesenchymal stromal epigenome is vital for applications in regenerative medicine, trained immunity, and immune reprogramming.
- Chromatin biology offers promising avenues for leveraging MSCs in therapeutic strategies.
- Further research into MSC epigenetic regulation can advance precision medicine.
Keywords:
cell differentiationchromatin remodelingepigeneticsgene regulationhematopoiesisinflammationinnate immunitymesenchymal stem cells (MSCs)tumor microenvironmentMore Related Videos
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