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Related Experiment Video

Updated: Nov 25, 2025

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

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Published on: July 6, 2017

Management of Malignant Colon Polyps.

Rodrigo Pedraza¹, Ragavan Siddharthan²

¹Gastrointestinal and Minimally Invasive Surgery Division, The Oregon Clinic, Portland, Oregon.

Diseases of the Colon and Rectum

|December 18, 2020

Summary

A screening colonoscopy revealed a sigmoid polyp with invasive carcinoma. Surgical resection confirmed the cancer and identified positive lymph nodes, necessitating adjuvant chemotherapy.

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Area of Science:

Gastroenterology
Surgical Oncology
Pathology

Background:

Screening colonoscopy is crucial for early detection of colorectal polyps.
Colorectal polyps can harbor adenomas or invasive carcinoma.
Early-stage colorectal cancer detection impacts treatment and prognosis.

Observation:

A 54-year-old woman underwent screening colonoscopy, identifying four polyps.
A 12-mm sigmoid polyp was removed and diagnosed as poorly differentiated invasive carcinoma with lymphovascular invasion.
Staging revealed 2/18 positive lymph nodes after surgical resection.

Findings:

The sigmoid polyp demonstrated submucosal invasion (0.8 mm) and positive deep margin (0.6 mm).
Laparoscopic sigmoid resection confirmed the polypectomy site and revealed residual disease.
Metastasis to regional lymph nodes was confirmed (2 out of 18 nodes).

Implications:

This case highlights the importance of thorough pathological examination of polyps.
Prompt surgical intervention and adjuvant therapy are critical for managing invasive colorectal cancer.
Accurate staging and lymph node assessment are essential for treatment planning.