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Long-acting injectable HIV therapies: the next frontier
John Thornhill1,2, Chloe Orkin1,2
1Department of Infection & Immunity, The Royal London Hospital, Bart Health NHS Trust.
Current Opinion in Infectious Diseases
|December 18, 2020
Summary
Long-acting injectable antiretroviral therapy (ART) shows promise for HIV management, with monthly and two-monthly options available. Challenges remain in cost-effectiveness and equitable access for all populations.
Area of Science:
- Infectious Diseases
- Pharmacology
- Public Health
Background:
- Significant advancements in long-acting injectable antiretroviral therapy (ART) are emerging.
- These therapies have the potential to transform the landscape of HIV care.
- This review focuses on the current state and future challenges of long-acting ART.
Purpose of the Study:
- To summarize the latest data on long-acting injectable ART.
- To outline the potential challenges associated with implementing these therapies.
- To provide an overview of the evolving field of HIV management.
Main Methods:
- Review of recent large-scale phase 3 randomized control trials.
- Analysis of early-phase studies for novel ART agents.
- Examination of clinical trial data for efficacy and safety.
Main Results:
- Monthly and two-monthly long-acting ART (cabotegravir and rilpivirine) demonstrated safety and efficacy in trials.
- Novel agents like Lenacapavir are in development, potentially allowing for six-monthly dosing.
- Evidence indicates patient acceptability and efficacy of these long-acting options.
Conclusions:
- Integrating long-acting ART into healthcare infrastructure presents significant challenges.
- Ensuring cost-effectiveness and accessibility for all populations is crucial.
- Future efforts must focus on real-world implementation to benefit those most in need.
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