Integration of TaO with Bi₂S₃ for Targeted Multimodality Breast Cancer Theranostics

Early identification and treatment of breast cancer is very important for breast conserving therapy and to improve the prognosis and survival rates of patients. Multifunctional nanotheranostic agents are of particular importance in the field of precise nanomedicine, since they can augment the visualization and treatment of cancer. We developed a novel Bi₂S₃ nanoparticle coated with a hyaluronic acid (HA)-modified tantalum oxide (TaO) nanoshell (Bi₂S₃@TaO-HA). The as-prepared core/shell nanoparticles exhibited a high Bi₂S₃ nanoparticle loading efficiency of (67 wt %). The TaO nanoshell exhibited excellent biocompatibility and computed tomography imaging capacity, and the Bi₂S₃ nanoparticles exhibited an excellent photothermal transducing performance and computed tomography (CT) and photoacoustic imaging capacity. As a result of these merits, the Bi₂S₃@TaO core-shell nanoparticles can act as a theranostic agent for CT/photoacoustically monitored enhanced photothermal therapy. These findings will evoke new interest in future cancer therapeutic strategies based on biocompatible functional nanomaterials.