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Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
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Paediatric endodontics Part 2: Pulp regeneration: current approaches.

E Milia1, S Eramo2, C D'Arcangelo3

  • 1Department of Medicine, Surgery and Experimental Science, University of Sassari, Sassari, Italy.

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|December 18, 2020
PubMed
Summary
This summary is machine-generated.

Regenerative Endodontic Procedures (REPs) aim to restore dental pulp. Current strategies like cell transplantation and cell homing show promise but depend on tooth condition, with root canal treatment still standard for mature necrotic teeth.

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Area of Science:

  • Dentistry
  • Regenerative Medicine
  • Endodontics

Background:

  • Dental pulp regeneration seeks to restore damaged pulp-dentine complex.
  • Regenerative Endodontic Procedures (REPs) represent a biologically-based approach.
  • Current REPs focus on restoring physiological functions of the tooth.

Purpose of the Study:

  • To provide an overview of current dental pulp regeneration strategies.
  • To discuss the clinical applicability and limitations of existing REP approaches.
  • To highlight the standard of care for specific dental conditions.

Main Methods:

  • Review of existing literature on dental pulp regeneration.
  • Analysis of cell transplantation and cell homing strategies for REPs.
  • Evaluation of factors influencing REP success, including tooth condition.

Main Results:

  • Two primary clinical strategies for REP induction are cell transplantation and cell homing.
  • The success of cell homing strategies is contingent upon the tooth's clinical and biological status.
  • Root canal treatment remains the established procedure for mature teeth with necrotic pulps and closed apices.

Conclusions:

  • Dental pulp regeneration is an evolving field with distinct clinical strategies.
  • REP success is highly dependent on patient-specific factors and tooth condition.
  • Further research may be needed to overcome limitations of current regenerative approaches.