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A Rat Model of EcoHIV Brain Infection
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AIDS-related progressive multifocal leukoencephalopathy
Carolina de Oliveira Abrão1, Lissa Rodrigues Machado da Silva1, Luiz Carlos Silva Souza1,2
1Secretaria de Estado da Saúde de Goiás, Hospital de Doenças Tropicais Dr. Anuar Auad, Goiânia, GO, Brasil.
Introduction:
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by reactivation of JC virus (JCV).
Methods:
We described the profile of laboratory-confirmed PML cases among AIDS patients.
Results:
A total of 43 HIV patients with clinical conditions compatible with PML were obtained; 5 cases were confirmed by JCV testing. The main clinical finding was mental confusion. Median CD4 count was 54 cells/mm³.
Conclusions:
Three of the five confirmed PML cases died; the time between diagnosis and death was 2, 5, and 6 months. It is important to consider JCV infection as a differential diagnosis.
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