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Related Experiment Video

Updated: Nov 25, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

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Published on: July 31, 2019

LSD alters dynamic integration and segregation in the human brain.

Andrea I Luppi¹, Robin L Carhart-Harris², Leor Roseman²

¹Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.

|December 18, 2020

Summary

Lysergic acid diethylamide (LSD) alters brain connectivity dynamics over time, increasing complexity in segregated brain states. These temporal brain changes correlate with subjective psychedelic experiences like ego dissolution.

Keywords:

Complexity FMRI dynamics Integration-segregation LSD Small-world network Structure-function

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Area of Science:

Neuroscience
Psychopharmacology
Cognitive Science

Background:

Investigating psychedelic substances like LSD offers insights into brain-mind interactions.
LSD is known to increase brain complexity, potentially linked to rich subjective experiences.
Previous research has not examined the dynamic effects of LSD on functional brain connectivity.

Purpose of the Study:

To investigate the time-resolved effects of LSD on dynamic functional connectivity and network properties (integration and segregation).
To correlate these dynamic brain changes with subjective psychedelic experiences.

Main Methods:

Utilized resting-state functional MRI (fMRI) combined with graph theory and dynamic functional connectivity analysis.
Examined temporal changes in brain network properties, specifically integration and segregation.
Correlated dynamic network measures with subjective reports of psychedelic experiences.

Main Results:

LSD's effects on brain function and subjective experience are time-dependent.
LSD increases complexity in globally segregated brain network states and weakens functional-anatomical connectivity.
Reduced anterior medial prefrontal cortex functional connectivity was observed under LSD, particularly during high segregation states.
Ego dissolution was associated with increased small-world organization during high global integration.

Conclusions:

Altered brain connectivity under LSD is nuanced and temporally specific.
Dynamic changes in functional connectivity and network organization are key to understanding psychedelic effects.
The study provides a more detailed temporal perspective on how LSD affects brain dynamics and subjective consciousness.