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COVID-19 and thrombosis: From bench to bedside

Mohammad A M Ali1, Sarah A Spinler2

  • 1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York- Binghamton, NY, USA.

Trends in Cardiovascular Medicine
|December 18, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) increases the risk of blood clots. This review examines COVID-19

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Hematology

Background:

  • COVID-19, a respiratory illness caused by SARS-CoV-2, is linked to increased risk of venous and arterial thromboembolic events.
  • The association between COVID-19 and thrombosis is a significant area of scientific interest.
  • Understanding this link is crucial for patient management and treatment strategies.

Purpose of the Study:

  • To review current knowledge on the association between COVID-19 and thrombosis.
  • To explore molecular and cellular mechanisms underlying COVID-19-associated thrombosis.
  • To evaluate antithrombotic agents in COVID-19 management and discuss clinical guidelines.

Main Methods:

  • Literature review of studies investigating COVID-19 and thromboembolic events.
  • Analysis of molecular and cellular pathways implicated in COVID-19 pathogenesis and thrombosis.
  • Review of clinical trials and guidelines concerning antithrombotic therapies in COVID-19 patients.

Main Results:

  • COVID-19 significantly elevates the risk of both venous and arterial thrombosis.
  • Multiple molecular and cellular mechanisms contribute to the prothrombotic state in COVID-19.
  • Various antithrombotic agents show potential, with ongoing research and evolving clinical recommendations.

Conclusions:

  • COVID-19 presents a substantial thrombotic risk requiring careful management.
  • Further research into underlying mechanisms and effective antithrombotic strategies is essential.
  • Adherence to updated professional guidelines is critical for preventing and treating thromboembolism in COVID-19.

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