Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

483
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
483
Inflammatory Response01:28

Inflammatory Response

15.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.1K
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

835
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
835
Chronic Pharyngitis01:23

Chronic Pharyngitis

8.4K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
8.4K
Anatomy of Respiratory System I: Upper Respiratory Tract01:29

Anatomy of Respiratory System I: Upper Respiratory Tract

3.8K
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
3.8K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-range correlation effects at molecular level in the electrical double layer of imidazolium-based electrolytes.

Physical chemistry chemical physics : PCCP·2026
Same author

High-speed particle analysis using forward and backward two-dimensional angular optical scattering.

Optics letters·2026
Same author

Effects of a Reprometabolic Syndrome-Inducing Eucaloric High-Fat Diet on Insulin Sensitivity, Body Composition, the Lipidome, and the Microbiome.

Metabolites·2026
Same author

Minimally invasive capsule-string device enables spatially resolved microbiome profiling across the upper gastrointestinal tract.

Gut microbes·2026
Same author

Associations Between Complementary Feeding Approach, Dietary Intake, and Growth: A Secondary Analysis of the Maternal and Infant Nutrition Trial.

Journal of the Academy of Nutrition and Dietetics·2026
Same author

Ethanol exacerbates post-burn neuroinflammation and gut-brain barrier dysfunction which are associated with microbiome changes.

Alcohol (Fayetteville, N.Y.)·2026

Related Experiment Video

Updated: Nov 25, 2025

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

31.4K

Altered tissue specialized pro-resolving mediators in chronic rhinosinusitis.

Thad W Vickery1, Michael Armstrong2, Jennifer M Kofonow3

  • 1Department of Otolaryngology - Head & Neck Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|December 18, 2020
PubMed
Summary

Specialized pro-resolving mediators (SPMs) are implicated in chronic rhinosinusitis (CRS) beyond leukotrienes and prostaglandins. SPM levels differ in CRS subtypes and correlate with sinonasal bacteria, suggesting a role in persistent inflammation.

Keywords:
Airway inflammationChronic rhinosinusitisLipidomicsMicrobiome

More Related Videos

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas
10:25

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas

Published on: June 12, 2019

7.5K
Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.2K

Related Experiment Videos

Last Updated: Nov 25, 2025

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

31.4K
Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas
10:25

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas

Published on: June 12, 2019

7.5K
Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.2K

Area of Science:

  • Immunology
  • Microbiology
  • Biochemistry

Background:

  • Chronic rhinosinusitis (CRS) pathogenesis is linked to leukotrienes and prostaglandins.
  • Omega-3 and omega-6 derived lipid mediators, including specialized pro-resolving mediators (SPMs), may play a role in upper airway inflammation.

Purpose of the Study:

  • To investigate differences in SPM profiles among CRS subtypes and controls.
  • To explore the relationship between SPMs and sinonasal microbiota in CRS.

Main Methods:

  • Analysis of lipid mediator pathways using liquid chromatography/tandem mass spectrometry.
  • Profiling of bacterial taxa via 16S rRNA gene sequencing.
  • Collection of ethmoid sinus tissue and middle meatal swabs from 66 subjects (controls, CRSwNP, CRSsNP).

Main Results:

  • Resolvin D2 was elevated in both CRSwNP and CRSsNP compared to controls.
  • Lipoxin A4 was significantly increased in CRSwNP versus CRSsNP and controls.
  • Cigarette smoking correlated with lower levels of certain 15-lipoxygenase metabolites.
  • Several lipid compounds showed correlations with sinonasal microbiota, including Pseudomonas aeruginosa.

Conclusions:

  • Dysfunctional lipid mediator pathways, including SPMs, are present in CRS.
  • Dysregulated SPM signaling may contribute to persistent inflammation and bacterial colonization in CRS.
  • SPM analysis offers a broader understanding of CRS pathogenesis beyond traditional mediators.