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Nuclear Expression Loss of SSBP2 Is Associated with Poor Prognostic Factors in Colorectal Adenocarcinoma

Yumin Chung1, Hyunsung Kim2, Seongsik Bang2

  • 1Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul 03181, Korea.

Diagnostics (Basel, Switzerland)
|December 19, 2020
PubMed

Insights

Single-stranded DNA binding protein 2 (SSBP2) loss is common in colorectal cancer (CRC) and linked to poorer outcomes. SSBP2 acts as a tumor suppressor, potentially serving as a prognostic biomarker for CRC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Single-stranded DNA binding protein 2 (SSBP2) is implicated in DNA damage response and cancer cell growth arrest.
  • SSBP2 exhibits a tumor suppressor role, with its expression loss observed in various cancers.
  • The prognostic significance of SSBP2 in colorectal cancer (CRC) remains largely undetermined.

Purpose of the Study:

  • To investigate the correlation between SSBP2 nuclear expression and clinicopathological factors in colorectal cancer.
  • To evaluate the association of SSBP2 expression with overall survival (OS) and recurrence-free survival in CRC patients.
  • To determine the potential of SSBP2 as a prognostic biomarker for colorectal cancer.

Main Methods:

  • Immunohistochemistry was employed to assess SSBP2 nuclear expression in normal colonic mucosa, adenomas, primary adenocarcinomas, and metastatic carcinoma tissues.
  • Clinicopathological factors, OS, and recurrence-free survival data were collected and analyzed for 391 colorectal adenocarcinoma patients.
  • Univariate survival analysis was utilized to identify associations between SSBP2 expression and prognostic parameters.

Main Results:

  • Diffuse nuclear SSBP2 expression was present in normal mucosa and adenomas, but lost in 34.3% of primary and 76.3% of metastatic colorectal carcinomas.
  • Loss of SSBP2 expression significantly correlated with adverse prognostic factors, including vascular invasion and advanced pT category.
  • Reduced SSBP2 expression was associated with significantly shorter overall survival (OS) in CRC patients.

Conclusions:

  • Nuclear SSBP2 expression loss is a frequent event in colorectal and metastatic carcinoma tissues.
  • SSBP2 functions as a tumor suppressor in colorectal cancer.
  • SSBP2 expression status may serve as a valuable prognostic biomarker for predicting outcomes in colorectal cancer.
Keywords:
SSBP2colon cancerimmunohistochemistryprognosis

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