Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

6.0K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.0K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

6.4K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autofluorescence enhances intraoperative detection of parathyroid glands: a single-center comparative study.

Frontiers in endocrinology·2026
Same author

Risk of bone overstimulation in long-term PTH(1-34) therapy for hypoparathyroidism.

European journal of endocrinology·2026
Same author

Lesional dosimetry in <sup>131</sup>I refractory metastatic differentiated thyroid cancer with BRAFp.V600E or RAS mutation treated with trametinib +/- dabrafenib followed by radioactive iodine.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

NOX4-derived oxidative DNA damage impairs thyroid differentiation through an epigenetic mechanism in BRAF-mutated radioactive iodine refractory papillary thyroid cancer cells.

International journal of biological sciences·2026
Same author

Refractory hypothyroidism: Diagnostic evaluation and management strategies.

Annales d'endocrinologie·2026
Same author

Concomitant Immune Checkpoint Inhibitors Induced Central and Primary Adrenal Insufficiency: A Diagnostic Challenge.

JCEM case reports·2025

Related Experiment Video

Updated: Nov 25, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

784

Current practice in patients with differentiated thyroid cancer.

Martin Schlumberger1, Sophie Leboulleux2

  • 1Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy and Université Paris Saclay, Villejuif, France. martin.schlumberger@gustaveroussy.fr.

Nature Reviews. Endocrinology
|December 19, 2020
PubMed
Summary
This summary is machine-generated.

Management of differentiated thyroid cancer (DTC) has evolved significantly. Risk stratification guides tailored treatment and follow-up for DTC patients, with ongoing research for optimized care.

More Related Videos

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

4.3K
Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

1.2K

Related Experiment Videos

Last Updated: Nov 25, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

784
Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

4.3K
Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

1.2K

Area of Science:

  • Endocrinology
  • Oncology
  • Nuclear Medicine

Background:

  • Differentiated thyroid cancer (DTC) management has undergone substantial evolution over four decades.
  • Advances in understanding DTC biology and therapeutic modalities like surgery, radioiodine, and thyroid hormone therapy have transformed patient care.
  • Improved diagnostic tools, including serum thyroglobulin, neck ultrasonography, and advanced imaging (CT, MRI, SPECT-CT, PET-CT), enhance prognostic accuracy.

Purpose of the Study:

  • To review the changes in differentiated thyroid cancer management over the past four decades.
  • To highlight the importance of risk stratification in tailoring treatment and follow-up strategies for DTC patients.
  • To identify the need for prospective trials to optimize treatment intensity without compromising outcomes.

Main Methods:

  • Review of therapeutic advances in surgery, radioactive iodine (radioiodine), and thyroid hormone treatment.
  • Evaluation of improved diagnostic tools such as serum thyroglobulin, ultrasonography, and various imaging modalities.
  • Analysis of prognostic classifications and their impact on patient management strategies.

Main Results:

  • The majority of DTC patients are now classified as low-risk, with a <1% risk of cancer death and curable recurrences.
  • High-risk DTC patients (5-10% of all cases) experience most cancer-related deaths and frequent recurrences, necessitating aggressive management.
  • Intermediate-risk DTC management is often individualized, underscoring the need for tailored approaches.

Conclusions:

  • Current DTC management emphasizes risk stratification to guide treatment intensity and follow-up protocols.
  • High-risk DTC patients require more intensive therapeutic and monitoring strategies compared to low-risk individuals.
  • Further prospective trials are essential to refine treatment and follow-up strategies, aiming to de-escalate care safely for selected DTC patients.