Related Experiment Video
Updated: Nov 25, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.9K
Periodontitis as a risk factor for head and neck cancer
L-M Gasparoni1, F-A Alves, M Holzhausen
1Department of Stomatology A.C.Camargo Cancer Center São Paulo, Brazil marianna.serpa@accamargo.org.br.
Medicina Oral, Patologia Oral Y Cirugia Bucal
|December 19, 2020
Summary
Periodontitis, an oral inflammatory condition, may increase head and neck cancer (HNC) risk. Research suggests Porphyromonas gingivalis is a key factor, but more clinical studies are needed.
Area of Science:
- Oral Health
- Oncology
- Microbiology
Background:
- Periodontitis is a chronic inflammatory disease affecting gums and supporting bone.
- Head and neck cancer (HNC) encompasses malignancies of the oral cavity, pharynx, and larynx.
- Emerging evidence suggests a potential link between periodontitis and HNC development.
Purpose of the Study:
- To review existing literature on the association between periodontitis and head and neck cancer.
- To explore potential biological mechanisms linking these conditions.
Main Methods:
- A comprehensive literature search was performed in the PubMed database.
- Articles published between January 1999 and May 2020 were analyzed.
- Study limitations and biological pathways were critically evaluated.
Main Results:
- 13 studies met inclusion criteria from 4,232 initially identified articles.
- A majority of studies indicated an association between periodontitis and HNC.
- Porphyromonas gingivalis was identified as a potential common risk factor, with genetic and environmental factors also implicated.
Conclusions:
- While understanding of the periodontitis-HNC link is growing, robust clinical studies are essential.
- Advanced "omic" technologies are expected to further elucidate the complex relationship between these conditions.
Related Concept Videos
02:59Cancer Prevention
7.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.2K
01:19Psychoneuroimmunology: Diabetes and Cancer
152
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
152
01:21Tooth Anatomy
1.7K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
1.7K
01:26Assessment of the Mouth
756
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
756
01:30Pneumonia I: Introduction
509
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
509
01:23Chronic Pharyngitis
8.3K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
8.3K