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Respiratory Viruses Associated With Acute Wheezing in Hospitalized Young Children in Jordan

Olajumoke O Fadugba1, Zaid Haddadin2, Sylvie Muhimpundu2

  • 1Department of Medicine, Division of Allergy and Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Journal of the Pediatric Infectious Diseases Society
|December 19, 2020
PubMed

Insights

Respiratory syncytial virus and human metapneumovirus infections in young children increase the risk of acute wheezing. Human rhinovirus was not associated with wheezing in this study.

Area of Science:

  • Pediatric infectious diseases
  • Respiratory viral infections
  • Epidemiology

Background:

  • Acute wheezing in young children is a common clinical problem.
  • Viral infections are frequently implicated in pediatric respiratory illnesses.
  • Understanding specific viral associations is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the association between specific respiratory viruses and acute wheezing in hospitalized children.
  • To identify viruses linked to increased odds of acute wheezing in infants and toddlers.

Main Methods:

  • Cross-sectional viral surveillance study.
  • Inclusion of hospitalized children under 2 years of age in Amman, Jordan.
  • Analysis of viral detection and association with acute wheezing episodes.

Main Results:

  • Respiratory syncytial virus (RSV) was significantly associated with higher odds of acute wheezing.
  • Human metapneumovirus (hMPV) also showed a significant association with increased odds of acute wheezing.
  • Human rhinovirus (hRV) was not found to be associated with higher odds of acute wheezing in this cohort.

Conclusions:

  • RSV and hMPV are key viral contributors to acute wheezing in young children.
  • Longitudinal studies are recommended to explore the link between early viral infections and recurrent wheezing.

Keywords:
Jordanacute respiratory infectionsacute wheezinghuman metapneumovirusrespiratory syncytial virus

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