Related Experiment Video
Updated: Nov 25, 2025
07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
11.7K
Autism spectrum disorder and kidney disease
Joanna Clothier1, Michael Absoud2
1Department of Paediatric Nephro-urology, Evelina London Children's Hospital, Westminster Bridge Road, London, SE1 7EH, UK. Jo.clothier@gstt.nhs.uk.
Pediatric Nephrology (Berlin, Germany)
|December 19, 2020
Summary
Children with kidney disease often have neurodevelopmental issues, including autism spectrum disorder (ASD). Early recognition and tailored care are crucial for managing ASD in pediatric kidney patients.
Area of Science:
- Pediatric Nephrology
- Neurodevelopmental Disorders
- Autism Spectrum Disorder
Background:
- Neurodevelopmental impairments are frequently associated with pediatric kidney disease and bladder dysfunction.
- Autism spectrum disorder (ASD) is a common neurodevelopmental disorder affecting social interaction, communication, and behavior.
- There is growing evidence suggesting shared genetic and environmental factors in the pathogenesis of ASD and kidney disease.
Purpose of the Study:
- To highlight the association between pediatric kidney disease and autism spectrum disorder.
- To emphasize the need for early identification of ASD in children with kidney conditions.
- To discuss practical strategies for managing and supporting children with both ASD and kidney disease.
Main Methods:
- Literature review on neurodevelopmental impairments in pediatric kidney disease.
- Discussion of diagnostic criteria and clinical presentation of ASD.
- Exploration of potential shared etiological factors between ASD and kidney disease.
Main Results:
- Prevalence rates of ASD in pediatric kidney disease are currently unknown.
- Children with communication difficulties, anxiety, or challenging behaviors may require neurodevelopmental assessment.
- Understanding communication methods and implementing sensory, behavioral, and environmental adaptations are key care strategies.
Conclusions:
- A high index of suspicion for ASD is necessary in pediatric kidney patients presenting with specific behavioral and communication challenges.
- Clinicians and families must collaborate to provide necessary adjustments for investigations and treatments.
- Further research is needed to determine the prevalence of ASD in pediatric kidney disease and elucidate shared pathogenic mechanisms.
Related Concept Videos
01:19Autism Spectrum Disorder
703
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
703
01:25Chronic Kidney Disease I: Introduction
361
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
361
01:24Chronic Kidney Disease II: Clinical Manifestations
361
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
361
01:28Chronic Kidney Disease III: Interprofessional Care
208
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
208
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
145
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
145
01:24Nephrotic Syndrome I : Introduction
278
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
278