Postoperative Atrial Fibrillation After Cardiac Surgery: A Meta-Analysis

Postoperative atrial fibrillation (POAF) is common after cardiac surgery and linked to poorer short-term and long-term outcomes; however, conflicting evidence exists on stroke risk and how the index procedure affects outcomes. This study aims to provide a comprehensive review of the published outcomes of POAF after cardiac surgery, examined as a whole and by index procedure.

A systematic review of POAF after cardiac surgery was conducted. Outcomes related to POAF were analyzed in a meta-analysis, and aggregate survival data were derived to examine long-term survival.

Sixty-one studies with 239,018 patients were identified, the majority (78.7%) undergoing coronary surgery. POAF occurred in 25.5% of patients and was associated with significantly higher rates of early mortality and stroke (odds ratio [OR], 1.74; P < .001; and OR, 2.21, P < .001, respectively) along with longer intensive care and overall hospital length of stay (mean difference 0.8 days, P = .008; and mean difference 2.8 days, P < .001, respectively). After a median of 6.6 years (range, 0.5-20 years), mortality and stroke remained significantly higher for those with POAF (OR, 1.57, P < .001; and OR, 1.81, P = .001). Pooled hazard ratio for long-term mortality was significantly higher for patients who underwent coronary surgery compared with isolated valve surgery.

POAF is common after cardiac surgery and is associated with significantly higher rates of both short-term and long-term stroke and mortality as well as increased hospital stay. Differences in hazard for long-term survival may be due to the underlying pathophysiological risk factors for POAF, which differ by surgical procedure.