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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Urinary Bladder01:23

Urinary Bladder

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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Updated: Nov 25, 2025

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
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Wnt signalling pathway in bladder cancer.

Guanlin Wu1, Weidong Weng2, Pengfei Xia1

  • 1Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin 13125, Germany; Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin 13125, Germany.

Cellular Signalling
|December 19, 2020
PubMed
Summary

The Wingless (Wnt) signalling pathway plays a key role in bladder cancer (BC) development. Understanding its mechanisms can lead to new diagnostic markers and targeted therapies for this malignancy.

Keywords:
Bladder cancerUrothelial carcinomaWnt signalling pathway

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Area of Science:

  • Oncology
  • Molecular Biology
  • Urology

Background:

  • Bladder cancer (BC) is a common and highly malignant urinary system tumour.
  • Conventional treatments exist, but research is exploring molecular mechanisms for novel therapies.
  • The Wingless (Wnt) signalling pathway is implicated in various tumourigeneses.

Purpose of the Study:

  • To review existing research on the Wnt signalling pathway in bladder cancer.
  • To explore the substances and mechanisms involved in Wnt pathway regulation in BC.
  • To identify potential therapeutic targets and diagnostic biomarkers for BC.

Main Methods:

  • Literature review of studies on bladder cancer and the Wnt signalling pathway.
  • Analysis of molecular mechanisms and participating substances.
  • Synthesis of findings to guide future drug development and diagnostics.

Main Results:

  • The Wnt signalling pathway is significantly involved in the biological processes of bladder tumours.
  • Specific Wnt pathway components and their regulatory mechanisms are crucial in BC.
  • This pathway offers potential for developing targeted anticancer drugs and diagnostic markers.

Conclusions:

  • Elucidating the Wnt pathway's role in BC is vital for advancing diagnosis and treatment.
  • Targeting the Wnt pathway may yield effective, less toxic therapies for bladder cancer.
  • Further research into Wnt pathway modulators can identify new biomarkers and therapeutic strategies.