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Updated: Aug 18, 2026
Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow
Published on: March 15, 2021
Transcranial Doppler Ultrasound Evidence of Active Cerebral Embolization in COVID-19
Ayush Batra1, Jeffrey R Clark1, Katie LaHaye1
1Northwestern University, Feinberg School of Medicine, Ken and Ruth Davee Department of Neurology.
Insights
Transcranial Doppler (TCD) ultrasonography detected cerebral microemboli in three COVID-19 patients, including one on anticoagulation. This non-invasive method aids in evaluating hypercoagulability in hospitalized COVID-19 patients.
Area of Science:
- Neurology
- Infectious Diseases
- Vascular Medicine
Background:
- Coronavirus disease-2019 (COVID-19) is associated with cerebrovascular complications, including ischemic stroke.
- The presence and significance of cerebral microemboli in COVID-19 patients remain under investigation.
Objective:
To report six consecutive patients with confirmed coronavirus disease-2019 (COVID-19) who underwent Transcranial Doppler (TCD) ultrasonography evaluation for cerebral microemboli in the setting of suspected or confirmed acute ischemic stroke.
Methods:
Patient data were obtained from medical records from Northwestern Memorial Hospital, Chicago, IL between May and June 2020. All patients with confirmed COVID-19 who underwent clinical TCD ultrasonography for microemboli detection were included.
Results:
A total of eight TCD studies were performed in six patients with COVID-19 (4 men and 2 women, median age 65±5), four with confirmed ischemic stroke and two with refractory encephalopathy. Microemboli were detected in three male patients, two patients had suffered a confirmed ischemic stroke and one who developed prolonged encephalopathy. Microemboli of varying intensity were identified in multiple vascular territories in two patients, and microemboli persisted despite therapeutic anticoagulation in a third patient. Of the three patients without evidence of microemboli on TCD ultrasonography, two patients had suffered a confirmed ischemic stroke, while one remained with refractory encephalopathy.
Conclusions:
TCD ultrasonography for microemboli detection identified three patients with confirmed COVID-19 with evidence of cerebral arterial microemboli, including one who was therapeutically anticoagulated. TCD ultrasonography provides a non-invasive method for evaluating cerebral microemboli in patients with COVID-19 and may be useful in assessing response to treatment in cases with suspected or confirmed disorders of hypercoagulability. Further studies investigating the prevalence of cerebral microemboli and associated risk factors are needed to characterize their pathogenic mechanism and guide therapeutic interventions in hospitalized COVID-19 patients.
