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Updated: Nov 25, 2025

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
Published on: December 16, 2013
[Ultradian rhythms and oxidative stress in the tissue of the lymph nodes in ontogenesis.]
I S Rozhkova1, D L Teply2, E D Bazhanova2,3,4
1Astrakhan State Medical University, 121 Bakinskaya str., Astrakhan 414000; 2 Astrakhan State University, 20a Tatishcheva str., Astrakhan 414000, Russian Federation.
Abstract:
We studied the age-related features of the ultradian rhythms of levels of total protein and albumin in the lymph nodes under normal condition and chronic toxic oxidative stress condition using the chronobiological approach and the biochemical methods. During the experiment, we compared the rhythmic activity of levels of total protein and albumin in the rat lymph nodes in ontogenesis and during chronic exposure to sulfur-containing natural gas. The revealed fluctuations of the levels of total protein and albumin can be characterized as around-hourly (ultradian) rhythms, which period is approximately 20-40 to 60 minutes. The obtained experimental data indicate a decrease in the adaptive resistance of lymph node with age and the depletion of the antioxidant system of rats in aging. These results could have a practical value for the development of correction methods of negative effects of toxic oxidative stress in ontogenesis.
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