Related Experiment Video

Updated: Nov 25, 2025

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

8.8K

Results of reconstructive interventions in patients with ischemic cardiomyopathy

Vladimir M Shipulin1, Andrey S Pryakhin1, Sergey L Andreev1

  • 1Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Asian Cardiovascular & Thoracic Annals
|December 21, 2020
PubMed

Insights

Left ventricular reconstruction combined with coronary artery bypass grafting significantly improves chronic heart failure outcomes in ischemic cardiomyopathy patients. This surgical approach enhances functional capacity and reduces heart failure markers long-term.

Area of Science:

  • Cardiovascular Surgery
  • Cardiology
  • Heart Failure Management

Background:

  • Ischemic cardiomyopathy presents significant challenges in cardiac surgery.
  • Effective long-term treatment strategies for patients with chronic heart failure due to ischemic cardiomyopathy are crucial.

Purpose of the Study:

  • To evaluate the long-term effectiveness of left ventricular reconstructive interventions in patients with ischemic cardiomyopathy and chronic heart failure.
  • To compare outcomes of isolated coronary artery bypass grafting (CABG) versus CABG combined with left ventricular reconstruction.

Main Methods:

  • A study involving 178 patients with ischemic cardiomyopathy between March 2013 and December 2017.
  • Propensity score matching analysis to compare isolated CABG with CABG plus left ventricular reconstruction.
  • Primary endpoints included hospital mortality and long-term survival.

Main Results:

  • Propensity score matching resulted in 29 comparable pairs of patients.
  • 30-day hospital mortality and long-term all-cause mortality were similar between groups (6.8% vs 6.8%, p=0.952 and p=0.352, respectively).
  • Patients undergoing CABG with left ventricular reconstruction showed significant improvements in peak oxygen consumption (p=0.043) and reduced N-terminal pro-brain natriuretic peptide levels (p=0.032) compared to isolated CABG.

Conclusions:

  • Coronary artery bypass grafting combined with left ventricular reconstruction offers significant long-term benefits for patients with ischemic cardiomyopathy.
  • This combined surgical approach leads to a notable decrease in clinical and functional parameters of chronic heart failure postoperatively.
  • Left ventricular reconstruction is a valuable adjunct to CABG for improving heart failure indicators in this patient population.
Abstract

Keywords:
Cardiac surgical procedurescoronary artery bypassheart failureheart ventriclesleft ventricular remodelingventricular dysfunction

More Related Videos

Author Spotlight: Enhancing Coronary Artery Revascularization05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

1.0K
Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.3K

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
127
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
177
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
232
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
164
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
161