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Plant based cross-linkers for tissue engineering applications.

Abhishek Indurkar1, Ashish Pandit2, Ratnesh Jain2

  • 1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India.

Journal of Biomaterials Applications
|December 21, 2020
PubMed
Summary

Plant-based cross-linkers are emerging as sustainable alternatives in tissue engineering. These natural compounds enhance scaffold properties, promoting cell growth and offering antimicrobial benefits for biomedical applications.

Keywords:
Plant-basedcross-linkershydrogelscaffoldtissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Green Chemistry

Background:

  • Synthetic cross-linkers in tissue engineering face limitations.
  • Plant-derived cross-linkers offer sustainable and renewable alternatives.
  • Natural cross-linkers are sourced from vegetative plant components, termed 'green' materials.

Purpose of the Study:

  • To review recent advancements in plant-based cross-linkers for scaffold synthesis.
  • To highlight the advantages of natural over synthetic cross-linkers.
  • To explore diverse biomedical applications of plant-derived cross-linked scaffolds.

Main Methods:

  • Literature review of plant-based cross-linkers in tissue engineering.
  • Analysis of natural compounds like ferulic acid and genipin.
  • Evaluation of scaffold properties influenced by natural cross-linkers.

Main Results:

  • Plant-based cross-linkers promote cellular proliferation, growth, and angiogenesis.
  • Natural compounds confer antimicrobial, antioxidant, and anti-inflammatory properties to scaffolds.
  • Scaffolds synthesized with natural cross-linkers exhibit enhanced versatility for various applications.

Conclusions:

  • Plant-based cross-linkers significantly enhance scaffold functionality for tissue engineering.
  • Natural cross-linkers offer a promising avenue for developing advanced biomedical scaffolds.
  • The integration of plant-derived molecules provides tunable properties for diverse therapeutic applications.