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The Hydroxamic Acids as Potential Anticancer and Neuroprotective Agents.

Margarita E Neganova1, Sergey G Klochkov1, Yulia R Aleksandrova1

  • 1Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Russian Federation.

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Hydroxamic acids show potential for treating cancer and neuropathologies by inhibiting histone deacetylase enzymes. Their multifunctional nature allows targeting multiple pathways in diseases like cancer and neurodegeneration.

Keywords:
Hydroxamic acidscancerhistone deacetylase.mitochondrianeurodegenerative diseasesoxidative stress

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Area of Science:

  • Medicinal Chemistry
  • Neuroscience
  • Oncology

Background:

  • Hydroxamic acids are recognized for their antitumor properties, mainly via histone deacetylase inhibition.
  • Emerging evidence highlights their potential in treating neuropathologies.
  • Their ability to target multiple molecular pathways offers therapeutic advantages.

Purpose of the Study:

  • To review the multifaceted roles of hydroxamic acids in combating cancer and neurodegenerative diseases.
  • To explore their impact on key pathogenetic mechanisms in both conditions.

Main Methods:

  • Literature review of experimental data on hydroxamic acids.
  • Analysis of their effects on molecular targets relevant to cancer and neurodegeneration.

Main Results:

  • Hydroxamic acids demonstrate broad biological activities applicable to oncology and neurology.
  • They act on common molecular targets, including histone deacetylases, mitochondria, and oxidative stress pathways.
  • This dual action supports their potential as multifunctional therapeutic agents.

Conclusions:

  • Hydroxamic acids are promising candidates for treating both cancer and neurodegenerative disorders.
  • Their ability to modulate epigenetic regulation via histone deacetylase inhibition is a key therapeutic mechanism.
  • Further research into hydroxamic acids could lead to novel treatments for complex diseases.