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Related Experiment Video

Updated: Nov 25, 2025

Microfluidic Applications for Disposable Diagnostics
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A disposable smart microfluidic platform integrated with on-chip flow sensors.

Jinho Kim1, Hyungseok Cho1, Junhyeong Kim1

  • 1Department of Nanoscience and Engineering, Center for Nano Manufacturing, Inje University, Gimhae-si, 50834, South Korea.

Biosensors & Bioelectronics
|December 21, 2020
PubMed
Summary

This study presents a disposable smart microfluidic platform (DIS-μChip) for automated fluid control. The novel platform integrates on-chip flow sensors for precise control and self-diagnosis in various applications.

Keywords:
DisposableFully automatedMicrofluidic platformOn-chip flow sensorsSelf-diagnosis

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Sensor Technology

Background:

  • Commercialization of microfluidic devices is limited by challenges in automated, low-cost, accurate, and safe fluid flow control.
  • Existing microfluidic systems often lack integrated sensing and self-diagnosis capabilities, hindering widespread adoption.

Purpose of the Study:

  • To introduce a disposable smart microfluidic platform (DIS-μChip) enabling full automation and self-diagnosis.
  • To demonstrate the platform's versatility and effectiveness in biological and clinical applications.

Main Methods:

  • Integration of on-chip microfluidic flow sensors at all inlet and outlet channels for automated pressure control and monitoring.
  • Fabrication of a disposable polymeric microchannel superstrate (polydimethylsiloxane microchannel with polyethylene terephthalate film) and a permanent multifunctional substrate.
  • Assembly and disassembly of the platform using vacuum pressure, enabling a disposable superstrate to prevent cross-contamination.

Main Results:

  • The DIS-μChip achieves full automation through integrated flow sensors and a pressure control system.
  • The platform provides a self-diagnosis function by monitoring all input and output flow rates.
  • Successful isolation of circulating tumor cells from pancreatic cancer patient blood and subsequent genetic analysis using droplet digital PCR.

Conclusions:

  • The DIS-μChip offers a low-cost, simple, accurate, and safe solution for automated microfluidic fluid control.
  • The disposable nature of the superstrate effectively prevents biological cross-contamination, a significant advantage over conventional systems.
  • The platform demonstrates high utility in complex clinical applications, such as cancer cell isolation and genetic analysis.