Related Experiment Video
Updated: Nov 25, 2025

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
Published on: October 7, 2017
Tolerability of lacosamide rapid dose titration: A randomized, multicenter, prospective, open-label study
Yong-Won Shin1, Jangsup Moon2, Yong Won Cho3
1Center for Hospital Medicine, Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea; Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea.
Rapid titration schedules for lacosamide are safe and effective for epilepsy patients. Shortened titration periods do not increase adverse events compared to conventional methods, making faster dosing feasible.
Area of Science:
- Neurology
- Pharmacology
Background:
- Current lacosamide dosing guidelines recommend lengthy titration periods.
- Clinical practice suggests rapid titration may be tolerated.
Purpose of the Study:
- To evaluate the safety and tolerability of rapid lacosamide titration schedules.
- To compare rapid versus conventional titration protocols for lacosamide.
Main Methods:
- Two rapid titration protocols (1 week to 400 mg/day) were compared to a conventional protocol (3 weeks).
- Safety outcomes, including adverse events and dose reductions, were assessed.
- Responder rates and plasma concentrations were analyzed.
Main Results:
- No significant difference in safety outcomes was observed among the three titration groups.
- Adverse events were dose-dependent, with most occurring after reaching the target dose.
- Concomitant use of sodium channel blockers increased the risk of adverse events.
Conclusions:
- Rapid lacosamide titration is a safe alternative to conventional methods.
- Shorter titration intervals are feasible for initiating lacosamide treatment in suitable patients.
More Related Videos
Related Concept Videos
Dosage Regimens: Partial Pharmacokinetic Parameters
Bioavailability Study Design: Single Versus Multiple Dose Studies
Dosage Regimen: Individualization
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Bioavailability Study Design: Healthy Subjects Versus Patients

