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Silicone and rheumatic diseases.

L P Endo1, N L Edwards, S Longley

  • 1Department of Medicine, College of Medicine, University of Florida, Gainesville 32610.

Seminars in Arthritis and Rheumatism
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

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Silicone implants may trigger inflammatory and rheumatic diseases. Evidence suggests a link between silicone exposure and conditions like arthritis and autoimmune responses.

Area of Science:

  • Immunology
  • Rheumatology
  • Biomaterials Science

Background:

  • Silicone is traditionally considered biologically inert.
  • Emerging evidence indicates potential inflammatory reactions to silicone materials.

Observation:

  • Clinical observations include granulomatous skin reactions, synovitis around joint prostheses, and lymphadenopathy near silicone implants.
  • Systemic rheumatic diseases have been anecdotally linked to silicone prostheses, particularly breast implants.

Findings:

  • Reported symptoms post-breast augmentation include tenderness, adenopathy, skin changes, arthritis, Raynaud's phenomenon, and positive rheumatoid factors and antinuclear antibodies (ANAs).
  • Experimental and clinical data support a direct inflammatory response to liquid or particulate silicone.

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Implications:

  • These findings suggest a potential association between silicone exposure and inflammatory and rheumatic diseases.
  • Further research is warranted to confirm the causal relationship and understand the mechanisms involved.