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An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
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New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of

Bei Guo1, Tongtian Zhuang2, Feng Xu1

  • 1National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Physiology
|December 21, 2020
PubMed

Insights

C1q tumor necrosis factor-related protein 3 (CTRP3), a key adipocytokine, plays a vital role in regulating metabolism and protecting the cardiovascular system. This review highlights CTRP3

Area of Science:

  • Endocrinology
  • Metabolic research
  • Cardiovascular science

Background:

  • Adipose tissue functions as a significant endocrine organ, releasing adipocytokines that influence metabolism and disease.
  • C1q tumor necrosis factor-related protein 3 (CTRP3), a paralog of adiponectin, is identified as a crucial adipocytokine.
  • CTRP3 exhibits diverse physiological roles, including the regulation of glucose and lipid metabolism, inflammatory responses, and cardiovascular protection.

Purpose of the Study:

  • To provide a comprehensive overview of the current research on CTRP3.
  • To explore the multifaceted roles of CTRP3 in metabolic and cardiovascular diseases.

Main Methods:

  • Literature review of recent studies on CTRP3.
  • Synthesis of findings related to CTRP3's involvement in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.

Main Results:

  • CTRP3 significantly impacts glucose and lipid metabolism.
  • CTRP3 demonstrates anti-inflammatory and cardioprotective effects.
  • Emerging evidence links CTRP3 to the pathophysiology of obesity, diabetes, metabolic syndrome, and cardiovascular diseases.

Conclusions:

  • CTRP3 is a critical mediator in metabolic homeostasis and cardiovascular health.
  • Further research into CTRP3 holds potential for novel therapeutic strategies for metabolic and cardiovascular disorders.
Keywords:
CTRP3adipocytokinescardiovascular disordersinsulin resistancemetabolic syndromeobesitytherapeutic targetstype 2 diabetes mellitus

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