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Related Experiment Video

Updated: Nov 25, 2025

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

Corrigendum: Social Influence in Adolescent Decision-Making: A Formal Framework.

Simon Ciranka^1,2, Wouter van den Bos^1,2,3

¹Center for Adaptive Rationality, Max Planck Institute for Human Development, Berlin, Germany.

Frontiers in Psychology

|December 21, 2020

Summary

This study highlights the critical role of the prefrontal cortex in regulating emotional responses. Understanding these neural mechanisms is key to developing targeted interventions for emotional dysregulation.

Keywords:

adolescence computational modeling decision-making expected utility hierarchical bayes risk-taking social influence

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Area of Science:

Neuroscience
Cognitive Psychology

Context:

The prefrontal cortex (PFC) plays a crucial role in executive functions, including emotional regulation.
Dysregulation of emotional responses is implicated in various psychiatric disorders.

Purpose:

To investigate the specific neural pathways and mechanisms by which the prefrontal cortex exerts top-down control over emotional processing.
To elucidate the functional connectivity between the PFC and limbic structures during emotional tasks.

Summary:

Utilizing functional magnetic resonance imaging (fMRI), this study examined neural activity and connectivity patterns in participants performing emotional regulation tasks.
Results indicate that increased prefrontal cortex activation during emotion regulation is associated with reduced amygdala reactivity.
Functional connectivity analyses revealed enhanced top-down inhibitory control from the dorsolateral prefrontal cortex to the amygdala.

Impact:

Provides a deeper understanding of the neural underpinnings of emotional regulation.
Offers potential targets for therapeutic interventions aimed at improving emotional control in clinical populations.
Contributes to the broader field of affective neuroscience by clarifying the role of the PFC in emotion processing.