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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
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Multiple Rare Risk Coding Variants in Postsynaptic Density-Related Genes Associated With Schizophrenia Susceptibility

Tsung-Ming Hu1,2, Ying-Chieh Wang1, Chia-Liang Wu1,3

  • 1Department of Psychiatry, Yuli Branch, Taipei Veterans General Hospital, Hualien, Taiwan.

Frontiers in Genetics
|December 21, 2020
PubMed
Summary

Rare mutations in postsynaptic density (PSD)-related genes, particularly neuroligin (NLGN), SHANK, and disks large-associated protein (DLGAP) families, may contribute to schizophrenia by altering protein expression.

Keywords:
PSD genein vitrorare mutationresequencingschizophrenia

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