The EurValve model execution environment.

Area of Science:

• Computational fluid dynamics
• Medical device simulation
• Cardiovascular engineering

Background:

• Interventional procedures for valvular heart conditions require accurate outcome prediction.
• Developing patient-specific computational models can be computationally intensive.
• Reduced-order models (ROMs) offer a computationally efficient alternative for complex simulations.

Purpose of the Study:

• To present a dedicated high-performance computing (HPC) infrastructure for developing reduced-order models (ROMs).
• To describe a model execution environment for simulating interventional procedures in valvular heart disease.
• To enable the deployment of a decision support system for clinical use.

Main Methods:

• Design and implementation of a specialized HPC infrastructure.
• Development of a ROM for simulating valvular heart interventions.
• Creation of a model execution environment for parameter tuning and case simulation.
• Integration with the EurValve international collaboration for patient case processing.

Main Results:

• Successful development of an HPC infrastructure tailored for ROM creation.
• Establishment of a functional model execution environment enabling efficient simulation and parameter optimization.
• Demonstrated capability to process specific patient cases for clinical decision support.

Conclusions:

• The presented HPC infrastructure and ROM development environment facilitate efficient simulation of interventional procedures.
• The developed system can be deployed as a decision support tool for valvular heart condition treatment.
• This approach supports personalized medicine through patient-specific simulations within international collaborations.