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Updated: Nov 25, 2025

Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice
Published on: January 16, 2013
Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel
Casey E Romanoski1, Xinshuai Qi2, Shreya Sangam2,3
1Department of Cellular and Molecular Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA.
Abstract:
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.
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