Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

d-Amphetamine binding to brain lipid.

M A Goldberg, T Todoroff

    Neurochemical Research
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    d-amphetamine binds to brain phospholipids like phosphatidylserine, influencing its effects. This interaction with lipids, not cholesterol or gangliosides, may be key to the drug's pharmacology.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Satisfaction with dentist-patient interaction at the municipal polyclinic: level and affecting factors].

    Stomatologiia·2023
    Same author

    Insitu magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to <i>in vitro</i> investigations.

    Bioactive materials·2020
    Same author

    Effect of calcium phosphate materials on multipotent mesenchymal cells from exfoliated deciduous teeth (SHED cells) in vitro.

    Bulletin of experimental biology and medicine·2013
    Same author

    Derivatives of 6-methoxy-8-nitroquinoline; chlorination with sulfuryl chloride.

    The Journal of organic chemistry·2010
    Same author

    Attempts to find new antimalarials; derivatives of phenanthrene; amino alcohols of the type -CHOHCH2NR3, derived from 9-bromophenanthrene.

    The Journal of organic chemistry·2010
    Same author

    Attempts to find new antimalarials; derivatives of phenanthrene; amino alcohols of the type -CHOHCH(CH3)NR2 and amino ketones of the type COCH2CH2NR2 derived from 9-bromophenanthrene.

    The Journal of organic chemistry·2010
    Same journal

    Vorinostat Rescues Cognitive Deficits in a Neuroinflammatory Mouse Model: A Study of Sex Differences and the Underlying TLR4/NF-κB Mechanism.

    Neurochemical research·2026
    Same journal

    MST4 Regulates Microglia Neuroinflammation via Targeting PKM2 Nuclear Translocation in Epilepsy: An In Vivo and In Vitro Study.

    Neurochemical research·2026
    Same journal

    Correction to: Dual Antioxidant DH-217 Mitigated Cerebral Ischemia-Reperfusion Injury by Targeting IKKβ/Nrf2/HO-1 Signal Axis.

    Neurochemical research·2026
    Same journal

    Microglia-Dependent BDNF Signaling in the Dentate Gyrus Underlies the Antidepressant Effects of Gardiquimod, a Toll-Like Receptor 7 Agonist, in Chronically Stressed Mice.

    Neurochemical research·2026
    Same journal

    Cryptotanshinone Targets Ferroptosis in Glioma via the EGFR/ROS Signaling Pathway.

    Neurochemical research·2026
    Same journal

    Combined Puerarin and Magnesium Acetyl Taurate Intervention Mitigates Autism-Like Pathology Through Glutamatergic and MAPK Pathway Regulation.

    Neurochemical research·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Pharmacology

    Background:

    • d-amphetamine is a widely used stimulant drug.
    • Its precise interactions within brain tissue are not fully understood.
    • Investigating drug-tissue component interactions can elucidate pharmacological mechanisms.

    Purpose of the Study:

    • To investigate the interaction of d-amphetamine with various brain tissue components.
    • To identify specific brain lipids that bind to d-amphetamine.
    • To explore the relationship between lipid composition and drug binding.

    Main Methods:

    • Utilized a hexane-buffer partition coefficient technique.
    • Tested d-amphetamine binding against a brain lipid extract.
    • Assessed binding with individual phospholipids, cholesterol, and gangliosides.

    Related Experiment Videos

    Main Results:

    • d-amphetamine demonstrated binding to a brain lipid extract and several individual phospholipids.
    • Phosphatidylserine exhibited the highest binding affinity.
    • Phosphatidylethanolamine and dipalmitoyllecithin also showed significant binding.
    • Binding was correlated with the fatty acid composition of the phospholipids.
    • Cholesterol and gangliosides did not bind d-amphetamine.

    Conclusions:

    • Phospholipid binding of d-amphetamine is a significant interaction within brain tissue.
    • The fatty acid profile of phospholipids influences d-amphetamine binding.
    • This phospholipid-drug interaction may contribute to the overall pharmacological action of d-amphetamine.