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Updated: Nov 24, 2025
In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
Published on: May 4, 2017
Daratumumab Interference in Flow Cytometry Producing a False Kappa Light Chain Restriction in Plasma Cells
William Kleinot1, Nadine Aguilera1, Elizabeth L Courville1
1Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA.
Abstract:
False kappa light chain restriction on hematogones (normal B-lineage precursors) has been described in patients on the therapeutic anti-CD38 monoclonal antibody daratumumab. In this article, we present a novel case report of pseudo-kappa light chain restriction on lambda-restricted neoplastic plasma cells in a patient with progressive plasma cell myeloma while on daratumumab. Flow cytometric technologists and pathologists need to be aware of this potential diagnostic pitfall.
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