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Updated: Nov 24, 2025

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

[Prostatic fibrosis: Progress in studies].

Jia-Cheng Zhang¹, Fan Zhao², Yue Duan³

¹The Second School of Clinical Medicine, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang 310053, China.

Zhonghua Nan Ke Xue = National Journal of Andrology

|December 21, 2020

Summary

This summary is machine-generated.

Prostate fibrosis contributes to lower urinary tract symptoms (LUTS) even without prostate enlargement. Targeting inflammation and fibrosis offers potential new treatments for LUTS.

Keywords:

benign prostatic hyperplasia fibrosis inflammation lower urinary tract symptoms prostate

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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

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Published on: August 14, 2019

Area of Science:

Urology
Pathology

Background:

Lower urinary tract symptoms (LUTS) can occur in patients with normal prostate volume.
Prostate fibrosis is increasingly recognized as a significant contributor to LUTS, alongside benign prostatic hyperplasia (BPH) and smooth muscle dysfunction.

Purpose of the Study:

To provide a comprehensive overview of prostatic fibrosis.
To discuss the causes, diagnosis, and treatment of prostatic fibrosis in the context of LUTS.

Main Methods:

Review of existing scientific literature on prostatic fibrosis and LUTS.
Analysis of the pathogenesis involving myofibroblast differentiation, aggregation, and activation.
Exploration of etiological factors including inflammation, ischemia, hypoxia, and drug exposure.

Main Results:

Prostate fibrosis is linked to various causes of inflammation, ischemia, and hypoxia.
Myofibroblast activity plays a key role in the development of prostatic fibrosis.
Anti-inflammatory and anti-fibrotic approaches show promise for LUTS management.

Conclusions:

Prostatic fibrosis is a distinct pathological entity contributing to LUTS.
Understanding the pathogenesis of fibrosis is crucial for developing targeted therapies.
Future treatments for LUTS may focus on modulating fibrotic processes and inflammation.