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Extramammary Borderline Phyllodes Tumor Presenting as an Umbilical Mass
John Jackson1, Eleanor Walker1, Robert Bethune1
1Royal Devon and Exeter Hospital, Exeter, UK.
International Journal of Surgical Pathology
|December 21, 2020
Summary
This case report details a rare borderline phyllodes tumor (PT) found in the umbilical region, initially mistaken for a hernia. It is the first documented instance of an extramammary PT presenting at this location.
Area of Science:
- Oncology
- Pathology
- Dermatology
Background:
- Phyllodes tumors (PTs) are rare fibroepithelial neoplasms of the breast.
- Accessory breast tissue can occur along the mammary ridge or at distant sites.
- PTs are classified as benign, borderline, or malignant based on histology.
Observation:
- A 56-year-old female presented with an umbilical mass, suspected to be a strangulated hernia.
- Histological examination revealed a fibroepithelial tumor with leaf-like ducts and high mitotic activity.
- Focal infiltration into surrounding fat was noted.
Findings:
- Immunohistochemical studies showed diffuse positivity for estrogen receptor, mammaglobin, GCDFP-15, and CK7 in epithelial cells.
- The tumor's features were consistent with a borderline phyllodes tumor.
- This represents the first reported case of a PT presenting as an umbilical mass.
Implications:
- This case expands the known clinical presentations of phyllodes tumors.
- It highlights the possibility of extramammary PTs, even in unusual locations like the umbilicus.
- Further research into the behavior and origins of extramammary PTs is warranted.
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